Endocrine Abstracts

Parathyroid hormone (PTH) exerts important metabolic effects on the kidney and is responsible for regulating phosphate transport by proximal tubules and calcium absorption by distal tubules. These effects are mediated by the type 1 PTH receptor (PTH1R), which is prominently expressed in both nephron segments. However, the signaling pathways employed by proximal and distal PTH1Rs differ markedly. Recent work reveals the apparent basis by which PTH receptors signal through cAMP ...